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These CVOT findings are supported by a real-world study performed in over 3 million patients with T2DM from the United States, in which patients treated with SGLT2is did not have a higher risk of any or lower amputation compared with incretins or other glucose-lowering agents [77]
Whether the triple-agonist profile amplifies or alters those benefits is a question the TRIUMPH-Outcomes trial is specifically designed to answer
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[DOI] [PMC free article] [PubMed] [Google Scholar] 86.Reiss A.B., Gulkarov S., Lau R., Klek S.P., Srivastava A., Renna H.A., De Leon J
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