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10.1053/j.gastro.2007.09.005
Br J Pharmacol (2014) 171:72334
Effective pharmacotherapy for obesity is likely to require long-term, if not life-long, treatment, which makes it important to consider long-term adherence and weight loss efficacy, and the effects on obesity co-morbidities (particularly cardiovascular outcomes), safety (including potential adverse effects on muscle mass and bone health), and cost of poly-agonist therapy
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