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Chun JH, Butts A (2020) Long-acting GLP-1RAs: an overview of efficacy, safety, and their role in type 2 diabetes management

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It is not the same as an approved medicine, and the current safety picture is still developing through clinical trials

Because each sequence in the initial alignment has a length of 30 amino acids and each position can be mutated to one of 19 amino acids (20 if the position is gapped), this gives 570 single-step mutants in the first generation for each sequence in the training set, that is, 71,304 sequences, reducing to 69,639 sequences after removing duplicates

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