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People with certain genetic profiles show stronger appetite suppression in response to morning dosing, while others respond equally well regardless of time

A 5 to 10 beat per minute increase that a 35-year-old barely notices might cause fatigue, exercise intolerance, or shortness of breath in a 65-year-old

In the recent trial, dysesthesia, an abnormal skin sensation, occurred in 12.5% of patients on the highest dose, compared with 20.9% in the December trial, a positive development for analysts who had previously raised concerns about the drugs side effects