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It is important to understand that these in vitro models express a different hormonal cocktail and respond to different chemical stimuli than intestinal L-cells in vivo ( The more physiologically relevant studies make use of in vivo transgenic mice, ex vivo perfused intestines or, more recently, crypt organoids derived from human, mouse or porcine guts ( In situ immunostaining and FACS studies have demonstrated that the hormonal secretome of GLP-1-secreting-cells is anatomically dependent

[DOI] [PMC free article] [PubMed] [Google Scholar] 70.Kubota A., Takano H., Wang H., Hasegawa H., Tadokoro H., Hirose M., Kobara Y., Yamada-Inagawa T., Komuro I., Kobayashi Y

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