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GLP-1 (semaglutide or tirzepatide) Therapy in Older Adults: Balancing Benefit & Risk Beyond Age 65 Joshua Silva, MD Dec 12, 2025 4 min read Medically authored by Joshua Silva, MD | Evidence-Based Weight Loss at Potere Health MD Last clinically updated: December 2025 Many discussions about GLP-1 medications in older adults come from friends, family, or acquaintances , as well as online forums, news stories, and social media posts

DOI: 10.1007/s13555-021-00552-6 Leyden J, Stein-Gold L, Weiss J

Change history 14 May 2021 Incorrect xml tagging References Davies MJ, DAlessio DA, Fradkin J

Stopping abruptly reverses these adaptations, sometimes creating a temporary metabolic mismatch where blood sugar regulation is less efficient than before treatment