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doi:10.1007/s001250051335 119

-blockers have been shown to reduce mortality through various mechanisms, including the blockade of adrenergic receptors and reductions in heart rate, which can profoundly affect cellular metabolism and energy utilization (Tomiyama and Yamashina, 2014)

GLP-1/GIP medications help by: Reducing appetite Increasing fullness Decreasing food cravings However, studies have demonstrated that over time: Appetite suppression may soften slightly Portion sizes may slowly increase Energy needs fall as body weight decreases When calorie intake and calorie expenditure find a new equilibrium , weight loss slows or stops creating a plateau

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As people lost weight, Ortiz said, their diabetes often improved, and the medications began to be used for weight loss