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50.5% achieved at least 15% weight loss

The cartilage itself is not innervated, but nociceptive fibers innervate the synovium and joint capsule, subchondral bone and periosteum, meniscus and ligaments [83]

Earlier, Pfizer acquired Metsera in a ~$10B deal, bringing: MET-097i - a weekly/monthly injectable GLP-1 with strong Phase 2 signals MET-233i - an amylin analog for combination boosting Two oral GLP-1s entering first-in-human studies Combined with Pfizers own oral GIPR antagonist (PF-07976016), this forms a rebuilt, multi-mechanism cardiometabolic pipeline
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We used human GLP-1 as the starting point for our drug discovery program
