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Despite the assertion that SEM generally does not penetrate the BBB, there is intriguing evidence of localized distribution of SEM within the brain, particularly in the hypothalamus [63,64]

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mean body mass index (mBMI) was 36.7 8.7 kg/m 2 and 34.3 5.3 kg/m 2

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Nevertheless, multiple degradation-resistant and structurally distinct GLP-1RAs do not generate the same GLP-1 metabolites yet reduce blood pressure, increase heart rate, inhibit enterocyte chylomicron secretion and reduce the extent of myocardial infarction in rats and mice through mechanisms requiring the canonical GLP-1R [99, 105,106,107,108]