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An increased risk of diabetic retinopathy has been reported in a clinical trial of semaglutide, which has been hypothesised to be related to the magnitude and rapidity of glucose lowering [61]

Professional medical societies actively engage in developing clinical practice guidelines and treatment quality standards

The absolute incidence of pancreatitis in clinical trials has been consistently low across studies, typically affecting fewer than 1 in 200 patients over multi-year follow-up periods

Gold SL, Rabinowitz LG, Manning L, Keefer L, Rivera-Carrero W, Stanley S, et al

The mechanism of action of GLP-1RA to promote weight loss mainly includes the reduction of fat deposition through regulation of adipose tissue (lipolysis, fatty acid oxidation, and adipocyte differentiation) and the reduction of food intake through the central and peripheral nervous system