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When you are on GLP-1 drugs, what you eat can significantly impact your health and the effectiveness of the medication

Real needle-free GLP-1 options exist: the Wegovy oral pill (approved December 2025) produced 14% body weight loss in a 64-week trial, and orforglipron (Eli Lilly) is pending FDA review

doi: 10.1038/ncpendmet0017 13 KiefferTJHabenerJF

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The OB GLP-1R-induced decrease in sympathetic nerve activity is GABA-dependent and relays via the PVN We next aimed to identify the mechanisms leading to the decrease in SNS activity after activation of the GLP-1R in the OB, which was confirmed by the observed increase in cFos expression in the MCL after local Ex4 injection (Fig