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Report suspected adverse reactions through the MHRA Yellow Card Scheme to support ongoing medication safety monitoring

McGovern A, Tippu Z, Hinton W et al

Common locations for GLP-1 medication-related cramps: Calf muscles : Frequently reported, especially nocturnal cramps Feet and toes : Often presenting as painful curling or spasms Thigh muscles : Less commonly affected but reported by some patients Abdominal muscles : May be confused with digestive side effects Hands : Occasionally reported, especially with electrolyte imbalances Cramp characteristics: Duration : Typically last from a few seconds to several minutes Intensity : Range from mild tightness to painful spasms Timing : More common at night or after physical activity Trigger patterns : May increase after dose increases or with dehydration Online patient discussions reveal significant individual variation in cramping experiences

The quantification of N = 3 (normalized by input) is shown in Supplemental Figure 9E

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