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The SELECT Trial: Design and Key Findings The SELECT trial enrolled 17,604 patients aged 45 or older with a BMI of 27 or greater and established cardiovascular disease (prior heart attack, stroke, or symptomatic peripheral artery disease), but critically, none had diabetes .[1] This design was intentionalresearchers wanted to understand whether semaglutide's cardiovascular benefits extended beyond its known effects in diabetic populations

[DOI] [PMC free article] [PubMed] [Google Scholar] 293.Seino Y., Fukushima M., Yabe D

Findings showed that semaglutide was linked to a significantly lower AD risk, with the most pronounced risk reduction observed in comparison to insulin (hazard ratio [HR] 0.33, 95% CI: 0.210.51), and a somewhat lower, though still substantial, reduction when compared to other glucagon-like peptide-1 receptor agonists (GLP-1RAs

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For those primarily using semaglutide for weight loss, some studies have noted constipation in approximately 24% of participants