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To conduct a study for Asians, Novo Nordisk set the obesity criteria as BMI 25 kg/m2 or more, following the domestic standards for an obesity trial

Exp Gerontol 2023;174:112126.ArticlePubMedPMC 189

and Mareel, M.M., 1999

Instead, studies attribute shedding to the physiological stress of rapid weight loss and potential nutritional deficiencies if diet lacks adequate protein, iron, zinc, or B vitamins
Some men report changes in libido or erectile function, though these effects are likely related to weight loss or overall health improvements rather than the drug itself