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Indeed, Versanis Bio have tried a combination of bimagrumab and semaglutide in a prior phase 2a study assessing bimagrumab in patients with obesity and type 2 diabetes

Moreover, it has recently been reported that metformin inhibits the apical sodium-dependent bile acid transporter and thus may increase the concentration of bile acids in the intestine [12], which could stimulate GLP-1 secretion from L cells via the G-protein-coupled receptor TGR5 [13]

These medicines, now widely used in the UK for obesity, diabetes, and metabolic conditions, can support significant weight loss and improved blood sugar control

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DPP-4 inhibitors raise levels of these hormones, which include glucose-dependent insulinotropic polypeptides (GIP) and glucagon-like peptide-1 (GLP-1)