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Typical research dose Research dose-finding ranges of ~212 mg per week, titrated upward over several weeks

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consider Metformin dose reduction if A1C below 6.5% Week 24+: If A1C stable below 6.0%, consider further Metformin reduction with close monitoring The additive effects of combination therapy were suggested by the trial subgroup analyses

thus it is recommended that recipients with renal or hepatic impairment should be warned of the risk of metabolic acidosis

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