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For adults over 40, this is not a trivial concern

Both ligands had similar cAMP potency but the exendin-4-C16 showed 2.5-fold bias towards G protein recruitment and a 60% reduction in -arrestin-2 recruitment efficacy compared to exendin-4, as well as reduced GLP-1R endocytosis and preferential targeting towards recycling pathways

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Learn how to manage semaglutide side effects like nausea & fatigue

Semaglutide can be added to existing treatment to improve glycemic control and induce weight loss