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10.1016/s0140-6736(14)60976-4

Unlike some psychiatric drug candidates where the mechanism of action is poorly understood, the GLP-1 pathway in reward circuitry has been extensively mapped

Trends in prescribing anti-obesity pharmacotherapy for paediatric weight management: Data from the POWER Work Group

The short answer: the tablet pairs semaglutide with an absorption enhancer called SNAC (salcaprozate sodium) to help a tiny amount of drug make it across the GI barrier - with absorption happening predominantly in the stomach

In summary, GLP-1RAs offer a novel strategy for addiction treatment, with the potential to address both the neurobiological and physiological aspects of SUDs
