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Over CNS, the direct action on NTS, hypothalamic arcuate and surrounding structures, as well as the effect on the ventral tegmental area and nucleus accumbens may act on homeostatic and hedonic hunger, changing palatability and reward behavior

CrossRef Glucose tasting depletes intracellular calcium stores and impairs macrophage functionality Laura Schlautmann, Daniel Burgdorf, Shaunak Ghosh, Alina Schieren, Linda Klmpen, Isabel Sttzel, Julia Bremser, Michael Dngi, Elvira Mass, Valentin Stein, Thomas Quast, Waldemar Kolanus, Thorsten Lang, Eva Kiermaier, Marie-Christine Simon, Sven Burgdorf iScience.2025

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Thankfully, the participant recovered after stopping usage of the drug, but the outcome is still a blow to the pharmaceutical giant, which had previously discontinued development of another oral GLP-1 drug in 2023 after a patient suffered similar injuries