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PPAR2 is primarily expressed in adipose tissue and promotes the differentiation and proliferation of adipocytes, which are derived from fibroblasts, resulting in an increase in adiposity [26]
In poorly controlled diabetes, excess glucose in the blood is filtered into urine (glycosuria), drawing water with it through osmotic diuresisa process that causes frequent urination

Clinical studies have shown that tirzepatide may help reduce HbA1c levels in adults with type 2 diabetes

doi: 10.3892/ijmm.2018.3509 59 MadhuDHammadMKavalakattSKhadirATissA

With the right approach, you can mitigate many of these potential long-term risks
