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Diabetes 15, 30 (2025), Long-Term SELECT Trial: Semaglutide Cuts Cardiovascular Events by 20% beyond Weight Loss, Higher-Dose Semaglutide Achieves Historic 21% Weight Loss in Landmark STEP UP Trial, Can oral Semaglutide (Wegovy) 25 mg replace the Once-Weekly 2.4 mg Injection for Obesity?, Semaglutide Continues to Impress: Phase 3 Trial Shows Reversal of MASH (Metabolic Dysfunction-Associated Steatohepatitis),

doi: 10.1016/j.cmet.2016.04.011

Executive Summary Written by Jonathan Wright, British Clinical Pharmacist Last reviewed: February 2026 Glucagon-like peptide-1 (GLP-1) receptor agonists including semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro) have transformed the treatment of obesity and type 2 diabetes

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