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While the trial was not designed to formally disentangle weight lossmediated vs weightindependent mechanisms, the magnitude and durability of weight loss likely play a substantial role in risk modification. Clinicians should note that in SELECT, treatment discontinuation due to adverse events was 16% on semaglutide vs 8% on placebo, largely driven by GI events

doi: 10.1006/bbrc.2001.4885

The pharmacokinetics are well-characterized: peak plasma concentration 1 to 3 days post-dose, steady-state achieved after 4 to 5 weeks of consistent dosing, volume of distribution approximately 12.5 liters, and clearance approximately 0.035 L/hr

"We really want to consider the myth or perception or anxiety versus what does the evidence say?" she said