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When compared with placebo or other therapies, GLP-1 agonists were associated with an increased risk of biliary disease [23]: Overall biliary disease: RR 1.37(95% CI 1.231.52) Cholelithiasis: RR 1.27 (95% CI 1.101.47) Cholecystitis: RR 1.36 (95% CI 1.141.62) Mechanisms: Reduced gallbladder motility Rapid weight loss increased cholesterol saturation and gallstone formation
Other studies are also testing to see whether drugs like Ozempic might be helpful in the setting of substance abuse.

Buse et al., 2014)

de Toro-Martn, J

insulin dose at GLP-1RA initiation was only decreased if HbA1c was below 7.5% (60)
