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Dipeptidyl peptidase-4 inhibitors and bone fractures: a meta-analysis of randomized clinical trials

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doi: 10.1056/NEJMoa2403347 257 WilcoxTDe BlockCSchwartzbardAZNewmanJD

Evidence shows that the strongest genetic risk factor for late-onset AD is the E4 allele of the cholesterol transporter APOE (APOE4), besides, APOE4 could promote amyloid aggregation and impair clearance from the brain directly binding to A (63)