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"We just don't have data on the use of GLP-1 agonists in a pregnant population so we always err on the side of caution in terms of looking at the risks of birth defects," Ashton said

doi:10.1016/j.cmet.2019.09.015 01 02 03 04 1

Two trials fulfilling these criteria directly compared the short-acting GLP-1 RA lixisenatide with the long-acting GLP-1 RA liraglutide [17, 18]

however, animal studies have demonstrated that GLP-1 causes a decline in the infiltration of macrophages within adipose tissue [66] and reduces the production and expression of pro-inflammatory cytokines, such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), and MCP-1 [67]
