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By incorporating estrous monitoring into current pre-clinical biomedical research, experimenters can assess differential effects of drugs and doses across estrous phases, which will be critical for understanding how drugs interact with endogenous fluctuations in hormonal state 72

Galidesivir (BCX4430), an adenosine nucleoside derivative with wide-ranging action towards RNA viruses, is now being tested in COVID-19 (ClinicalTrials.gov Identifier: NCT03891420) that was effective towards flaviviruses like Zika

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