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Dosing Errors May Be More Common With Compounded GLP-1s Multiple adverse event reports were related to dosing mistakes with compounded semaglutide injections, which resulted from patients self-administering incorrect doses or healthcare providers miscalculating doses, the FDA said

The recurrence of symptoms in certain patients has been observed when reintroducing either the same drug or another from the same class [165]

A meta-analysis of clinical trials suggested that the highest dose of tirzepatide (15 mg) was associated with the highest risk for nausea, vomiting, and diarrhea when compared to a placebo and other doses

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A prolonged period of observation and treatment for these symptoms may be necessary, taking into account the long half-life of RYBELSUS of approximately 1 week