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Warfarin interaction is clinically relevant because GLP-1-induced changes in gastric emptying can alter absorption of narrow-therapeutic-index drugs, and QT prolongation matters because of the cardiac side-effect profile of some weight-loss adjuncts

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El ensayo STEP UP demuestra una prdida considerable de peso de ms del 20%, adems de los beneficios para la salud previamente demostrados con la semaglutida, coment Ludovic Helfgott, vicepresidente ejecutivo de Estrategia de Producto y Portafolio en Novo Nordisk

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Gastrointestinal side effectsincluding nausea, vomiting, diarrhea, constipation, and abdominal discomfortoccur in a substantial proportion of patients, particularly during dose escalation