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In fact, some researchers are proposing that GLP-1 and related drugs are the most important drug-class breakthrough in medical history. 2 There is one simple but intriguing question about this whole topic: How can one drug have so many seemingly unrelated benefits

Up to 55% of patients developed anti-drug antibodies [65], which were associated with systemic allergic reactions in approximately 5% of cases and injection-site hypersensitivity, including anaphylaxis, which necessitated early trial termination [66, 67]

Oral semaglutide absorption can be reduced by up to 60% when taken with food, requiring strict administration protocols

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