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doi: 10.1007/s40265-025-02263-0 5 WhartonSLingvayIBogdanskiPDuque do ValeRJacobSKarlssonTet al

A 68-week clinical trial of Wegovy was conducted with 1,961 adults

Its a structured, provider-guided program that uses GLP-1 therapy to support weight loss, hormone balance, and metabolic health during menopause

Best for Gut Health Replenza Daily Multi-Vitamin + Probiotics for GLP-1 Support Pros Contains probiotics and digestive enzymes Contains ashwagandha for stress relief Third-party certified by NSF Cons Contains wheat and soy Large tablets that may be difficult to swallow Key Specs Supplement form: Tablet Serving size: Two tablets Third-party tested: Yes Best Once Daily Pure Encapsulations O.N.E

Important observations All five clinical trials that were included in the analysis reported GLP-1 receptor agonist-mediated reduction in substance use disorder, with two trials respectively reporting a significant therapeutic impact of GLP-1 receptor agonist in reducing alcohol use disorder and nicotine use disorder