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Medication may not be appropriate for everyone

McIntyre: Glucagon-like peptide 1 (GLP-1) receptor agonists as a protective factor for incident depression in patients with diabetes mellitus: A systematic review

Although leave-one-out and Baujat analyses were performed, they did not meaningfully reduce heterogeneity, indicating that the variability is intrinsic to the studies themselves

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At maintenance doses of 8 to 12mg, the wearing-off effect is much less pronounced
