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Compelling evidence from landmark clinical trials, particularly STEP-HFpEF, STEP-HFpEF DM and SUMMIT, has established the efficacy of GLP-1RAs in improving HF-related symptoms and quality of life, as well as reducing worsening HF events, in the prevalent phenotype of HFpEF in the setting of obesity and T2D

Pancreatitis has been associated with GLP-1 medication use as well, though it is not among the more common side effects

According to the company's phase III clinical trial data, patients using oral Wegovy lost approximately 14% of their body weight when combined with reduced-calorie diet and exercise, with those remaining on treatment losing about 17% compared to approximately 3% for placebo recipients

If you experience these symptoms, check your blood glucose if possible, and if below 70 mg/dL, treat with 15 grams of fast-acting carbohydrate (such as glucose tablets or 4 oz of juice), then recheck in 15 minutes

Exenatide, lixisenatide, liraglutide, dulaglutide, and semaglutide have been shown to improve learning and memory while reducing A/tau pathology, neuroinflammation, and synaptic/metabolic deficits in rodent models of sporadic toxin-induced neuronal injury (A, streptozotocin, okadaic acid) (54, 111120), and in multiple transgenic strains (5FAD, 3Tg, APP/PS1, Tg2576, APP/PS1/Tau) (121, 121133)