glp 1 is tirzepatide GLP-1 use tripled among non-diabetics, reaching $5.8B in 2022 GLP-1 vs. GLP-1 + GIP:

While Eli Lilly recently introduced a new, cheaper version of Mounjaro and Zepbound (which comes in a vial instead of an injector pen), the price per month, which ranges from $400 to $550 depending on dosage, is still significantly higher than many of the compounded vials on offer

Using backup contraception for four weeks after starting and after each dose escalation is recommended

Overall, results from the cardiovascular outcomes trials (CVOTs) completed for all marketed GLP-1 RAs in type 2 diabetes support a benefit in HF specifically in addition to the approved use in broad CVD risk reduction in people with type 2 diabetes (Sattar et al., 2021)

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Those who were concurrently using GLP-1 receptor agonists had a 48% lower rate of UTIs (8.8% versus 13.3%) and a 74% lower rate of urinary retention compared to those not on GLP-1 therapy