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Synthesis, optimization, and biological evaluation of corrinated conjugates of the glp-1r agonist exendin-4

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In a mouse model of WHS with deletions of the Nsd2 gene, the animals exhibited growth retardation, midline, craniofacial, and ocular abnormalities, but showed no signs of learning deficits (Naf et al., 2001)

Serious adverse events Both compounds have been associated with rare but serious adverse events in clinical trials