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More patients living in high-SES score areas were in the Zepbound cohort than in the Wegovy cohort (40.75% vs
While most patients do not experience mood changes, higher-risk groups include: History of depression, anxiety, or bipolar disorder ADHD or dopamine-sensitive conditions Very rapid weight loss Inadequate protein or electrolyte intake Poor sleep quality Lower risk is associated with: Slow dose titration Adequate nutrition Stable blood sugar Good sleep hygiene What Clinicians and Patients Can Do Before Starting a GLP-1 Screen for mood disorders Set expectations about appetite changes Discuss minimum nutrition goals During Treatment Monitor caloric intake (not just weight) Prioritize protein and hydration Watch for glucose variability Adjust dose slowly If Irritability Appears Assess nutrition first Evaluate sleep and reflux Consider dose adjustment Monitor mood over time In many cases, simple nutritional adjustments or slower titration resolve symptoms without stopping the medication
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Repeated missed doses, however, will prevent steady state maintenance and reduce efficacy
High-fat and high-protein meals tend to slow digestion further and exacerbate the effect
