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Phase 3 trials are specifically monitoring cardiovascular outcomes, and anyone with a pre-existing heart condition would need careful assessment before starting retatrutide assuming it gains approval

Continuous doseresponse relationships were modeled using generalized additive models (GAMs), with percent weight change as the dependent variable and weekly dose (mg) modeled as a smooth function

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Ken Fujioka, an endocrinologist who leads the Scripps Clinic Nutrition and Metabolic Research Center in San Diego and who was not involved in the study, noted that the FDA approved a higher dose of Ozempic in March 2022 but that many doctors were not aware of that during the study period