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The SELECT trial specifically demonstrated that semaglutide reduces major adverse cardiovascular events by 20% in patients with established cardiovascular disease, regardless of diabetes status

According to a 2010 Contrave weight loss review published in Obesity , 1.5 times as many people taking Contrave with behavior therapy lost at least 5% of their body weight compared to people taking a placebo with behavior therapy

However, these methods have limitations, including low bioavailability, poor solubility, the need for high-dose administration, gastrointestinal side effects, and frequent dosing

and serious renal events, which included acute kidney injury, chronic kidney disease, hypertensive chronic renal disease, unspecified kidney failure, and renal complications of diabetes

Over one year, people taking Qsymia lost an average of 19 pounds more than placebo, those taking Contrave lost an average of 11 pounds, and those taking Xenical lost an average of nearly 6 pounds