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The GLP-1 receptor agonist drug class has revolutionized obesity treatment, but key unmet needs persist

GLP-1 receptor agonists have shown cardiovascular benefits beyond weight loss, including potential improvements in cholesterol profiles

In this article we provide an overview of the pathophysiology and management of NASH, with a special focus on the pharmacological effects and possible mechanisms of GLP-1 mimetics in treating NAFLD/NASH, including dual and triple agonists at GLP-1R, glucose-dependent insulinotropic polypeptide receptor or glucagon receptor.

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