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Antibodies targeting IL1- have also shown mixed, although more positive effects, particularly in reducing HbA1c with IL1- antagonism [206], with recent evidence suggesting that combined TNF-alpha and IL1- blockade may be most effective for glycemic control [207]

Please notify your provider if side effects persist

Oral orfoglipron, as opposed to peptide-based oral semaglutide, can be taken without regard to food timing

Do ODTs cause fewer side effects than injections

Nonetheless, they can be considered as a reasonable secondline addon therapy to metformin, specifically in situations where a more substantial reduction in HbA1c levels is necessary