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The PK data on ACEI and GLP1 agonist co-treatment showed different effects by different GLP1RAs (Table 3)

It was designed as a safety valve for exceptional circumstances

There are also side effects to consider, as well as cost and lack of long term safety data - the longest study duration is 2 years - a far cry from the lifetime of use most folks will need to sign-up for to see sustained change

Researchers who escalated too quickly bore the brunt of gastrointestinal side effects, while those who followed the standard four-week titration intervals reported significantly better tolerability

Here's what we advise our patients: Hydrate Relentlessly: Dehydration makes everything worse, especially nausea and fatigue