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In microglia, GLP-1R activation via PI3K/Akt signaling also reduces neuroinflammation by modulating NF-B activity, decreases the production of pro-inflammatory cytokines, increases anti-inflammatory markers such as IL-10, IL-4, Arginase, and CD206, and the transformation of microglia into an anti-inflammatory state

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Ozempic targets only GLP-1 receptors , which: Tirzepatide is a dual pathway medication, acting by mimicking the function of two hormones : This dual action helps: Tirzepatide is a dual-action medication working through GLP-1 and GIP pathways SURPASS-2 Trial: Tirzepatide versus Semaglutide (Ozempic) for diabetes In clinical trials, Tirzepatide gave improved results compared to Semaglutide (Ozempic) for diabetes control and weight loss