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Individuals with the following conditions should be considered higher-risk and would likely require specialist oversight: Established cardiovascular disease : patients with atherosclerotic cardiovascular disease may derive metabolic benefit from weight loss, but the modest increase in heart rate and haemodynamic changes associated with this drug class warrant careful monitoring

Another option is Zepbound (tirzepatide), which also works by increasing feelings of fullness and controlling hunger

~0.08mg 0.17mg 0.33mg 0.57mg 0.8mg 3x/week 3 injections/week P/T Ratio: ~1.5 Peak Reduction: 28% 4

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in vivo showed that -arrestin 2 normally promotes receptor degradation and limits sustained signaling [47]