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Glucose, as an osmotically active molecule, may reduce osmotic pressure by bringing water from the interstitium to the vessels, triggering retinal edema

Due to long half-lives, agents like semaglutide and tirzepatide must be discontinued at least 35 days before conception

Overall, our meta-analysis underscores the value of GLP-1RAs as a multifaceted therapeutic option, particularly in PCOS patients with obesity and IR

Effects of GLP-1 receptor agonist on changes in the gut bacterium and the underlying mechanisms

They are used without the need for dose titration and give broadly similar HbA1c lowering efficacy to other oral antidiabetic agents