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[133] The Blood Pressure Lowering Treatment Triallists Collaboration (BPLTTC) meta-analysis results, which included 48 clinical trials using antihypertensive drugs, showed that in patients with and without previous cardiovascular disease, a reduction of 5 mmHg in systolic blood pressure reduced the relative risk of major cardiovascular events by 9% and 11%, respectively

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Similarly, in a pooled analysis of results with semaglutide, a significant improvement was found in the annual impairment of eGFR, which was particularly pronounced in those with a baseline eGFR between 30 and 60 ml/min., but which remained significant in those with a higher baseline eGFR [30]

Taking doses closer than 48 hours apart may increase gastrointestinal side effects like nausea, vomiting, and diarrhea, and could affect blood glucose control