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Historical Lesson: The AOD-9604 experience illustrates why GLP-1 agonists dominate current obesity pharmacotherapyaddressing appetite and satiety (the input side) proves more effective than attempting to accelerate fat breakdown (the output side)
The willingness to keep taking medication can be influenced by the symptoms (or lack of) of the condition being treated

Diabetes Technol Ther 2018;20:639647 [DOI] [PMC free article] [PubMed] [Google Scholar] 192

This finding was supported by a double-blinded randomized controlled trial (RCT) that assessed the effect of pioglitazone as an adjuvant treatment on depressive symptoms