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In participants with obesity and chronic kidney disease without diabetes, once-weekly administration of semaglutide 2.4mg led to a reduction in albuminuria, body weight and systolic blood pressure compared with placebo, with no changes to creatinine or cystatin-C estimated glomerular filtration rate or measured glomerular filtration rate during the 24-week follow-up period.

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Some patients abandon therapy after reaching their target weight, while others are forced to pause or switch treatments due to supply shortages

Considerations for employers who are thinking about covering GLP-1 drugs for weight loss.