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In particular, we sought to update the results of previous meta-analyses by our group 13 and others (summarized in Supplemental Table-S1), 14 20 given the availability of new trial data from a GLP-1 RA RCT 21 and GIP/GLP-1 RA RCTs and provide comparative estimates for cardiovascular outcomes in GLP-1 RA or GIP/GLP-1 RA-treated T2DM patients