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Similarly, in the SURMOUNT-1 trial, all participants received lifestyle intervention which included regular counseling with a dietitian or qualified health professional to achieve a 500 kcal/day energy deficit and 150 minutes of physical activity weekly

Difference in Gastrointestinal Risk Associated with Use of GLP-1 Receptor Agonists: A Real-World Pharmacovigilance Study

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Additional supplements to consider include omega-3, vitamin D (especially for Canadians during fall and winter), magnesium, and electrolytes on days when hydration is a concern

However, there is currently no published data specifically on the combination of retatrutide and HRT