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These include the development of next-generation glucagon-like peptide-1 receptor agonists (GLP1Ras), with their weight loss efficacy ranging from 12% to 15% for semaglutide and 20% for tirzepatide (ZEPBOUND, 2024)

Teriparatide common side effects include nausea, headache, dizziness, and leg cramps

Some patients report pain improvement early in therapy, before significant weight reduction occurs

GLP-1 medicines and stroke Multiple preclinical studies demonstrate that GLP-1 medicines reduce brain injury and the extent of cognitive deficits, benefits largely attributed to protection against BBB deterioration, cytoprotection, and reduction of neuroinflammation and oxidative stress 13 , 86 , 87 (Figure 3)

[DOI] [PubMed] [Google Scholar] 220.Svegliati-Baroni G, Saccomanno S, Rychlicki C, Agostinelli L, De Minicis S, Candelaresi C, Faraci G, Pacetti D, Vivarelli M, Nicolini D, Garelli P, Casini A, Manco M, Mingrone G, Risaliti A, Frega GN, Benedetti A, Gastaldelli A