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(1) intravenous administration with EMPA (10 mg/kg, Adipogen life sciences, Liestal, Switzerland) followed by administration with PBS an hour after the administration with EMPA, (2) intravenous administration with LINA (10 mg/kg, Adipogen life sciences, Liestal, Switzerland) followed by administration with PBS at an hour, (3) concurrent administration with EMPA (10 mg/kg) and LINA (10 mg/kg) followed by administration with PBS at an hour, and (4) intravenous administration with EMPA followed by administration with LINA at an hour (10 mg/kg)

Across studies, treatment with GLP-1RAs led to reductions in urinary albumin excretion rate (UAER) or urine albumin-to-creatinine ratio (UACR), with improvements ranging from 24% to 29.7% in reductions

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Graas sua liberao gradual, Carolean contribui para a regulao do apetite sem causar desconfortos gastrointestinais, alm de favorecer uma maior absoro de nutrientes no intestino, estimulando a produo e liberao do GLP-1